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Birth Defects - Causes of defects, Physical birth defects, Hereditary diseases and syndromes

blood child heart oxygen

Birth defects or congenital defects are present at birth. They result from heredity, environmental influences, or maternal illness. Such defects range from the very minor, such as a dark spot or birthmark that may appear anywhere on the body, to more serious conditions that may result in marked disfigurement, impaired functioning, or decreased lifespan.

A number of factors individually or in combination may cause birth defects. Heredity plays a major role in passing birth defects from one generation to the next. Inherited conditions are passed on when a baby receives a flawed gene from one or both parents. Conditions such as sickle cell anemia, color blindness, deafness, and extra digits on the hands or feet are hereditary. The condition may not appear in every generation, but the defective gene usually is passed on. A classification of structural defect can be as follows: Malformation (poor formation), deformation (due to fetal constraint that can result in damage (e.g., central nervous system damage or limb reduction) and disruption of previous normally formed structures (due to vascular damage, vascular exchange of necrotic debris).


Low birth weight deriving from a fetal growth restriction (FGR) is the most common birth defect, with one in every 15 babies being born at less than their ideal weight. A baby whose weight lies in lowest 10% of the normal population is designated as having a FGR. At term of pregnancy, a baby who weighs 5 lb, 8 oz (2,500 g) at birth has a low birth weight. One who is born weighing 3 lb, 5 oz (1,500 g) has a very low birth weight. A low birth weight baby born after a normal gestation period is called a small-for-date or small-for-gestational-age baby.

Exposure of the mother to chemicals such as mercury or to radiation during the first three months of pregnancy may result in an abnormal alteration in the growth or development of the fetus. The mother's diet may also be a factor in her baby's birth defect. A balanced and healthy diet is essential to the proper formation of the fetus because the developing baby receives all of its nutrition from the mother.

Prenatal development of the fetus may also be affected by disease that the mother contracts, especially those that occur during the first trimester (three months) of pregnancy. For example, if a pregnant woman catches rubella, the virus crosses the placenta and infects the fetus. In the fetus, the virus interferes with normal metabolism and cell movement and can cause blindness (from cataracts), deafness, heart malformations, and mental retardation. The risk of the fetal damage resulting from maternal rubella infection is greatest during the first month of pregnancy (50%) and declines with each succeeding month.

It is especially important that the mother not smoke, consume alcohol, or take drugs while she is pregnant. Drinking alcohol heavily can result in fetal alcohol syndrome (FAS), a condition that is physically apparent. FAS newborns have small eyes and a short, upturned nose that is broad across the bridge, making the eyes appear farther apart than normal. These babies also are underweight at birth and do not catch up as time passes. They often have some degree of mental retardation and may exhibit behavior problems. A mother who continues to take illicit drugs such as heroin, crack, or cocaine will have a baby who is already addicted. The addiction may not be fatal, but the newborn may undergo severe withdrawal, unless the addiction is revealed and carefully treated. Furthermore, some behavior problems/cognitive deficits are suspected to be associated with fetal drug exposure and addiction.

Some therapeutic drugs taken by pregnant women have also been shown to produce birth defects. The most notorious example is thalidomide, a mild sedative-hypnotic agent. During the 1950s women in more than 20 countries who had taken this drug gave birth to more than 7,000 severely deformed babies. The pattern of malformation seen in affected infants included phocomelia, polydactyly, syndactyly, facial capillar hemangiomas, hydrocephalus, renal anomalies, cadiovascular anomalies, ear and eye defects, and intestinal anomalies. The principal defect these children suffered is phocomelia, characterized by extremely short limbs often with no fingers or toes.


Clubfoot

Approximately one newborn out of every 735 has a form of clubfoot. In the most serious form, known as equinovarus, the foot is twisted inward and downward and the foot itself is cupped or flexed. If both feet are clubbed in this manner the toes point to each other rather than straight ahead. Often the heel cord or Achilles tendon is taut so that the foot cannot be straightened without surgery.

A milder and more common type of clubfoot is called calcaneal valgus, in which the foot is bent upward and outward in the same way that you would flex your foot at the ankle. Still other forms include the talipes cavus in which the instep is abnormally elevated; talipes valgus in which the heel is turned outward, and talipes varus in which the heel is turned inward.

The seriously deformed clubfoot requires surgery to realign the bones and ligaments. The milder forms often can be cured by fitting the baby with corrective shoes to gradually move the bones back into alignment.


Cleft lip and cleft palate

Approximately 7,000 newborns (one of every 930 births) are born with cleft lip and/or cleft palate each year in the United States. Cleft lip and palate describe a condition in which a split remains in the lip and roof of the mouth. Although cleft lip and palate are two distinct anomalies, they frequently occur together. Cleft lip with or without cleft palate occurs in 60-75% of the cases. twenty-five to forty percent are isolated cleft palate. During growth in utero (in the womb) the lip or palate, which develop from the edges toward the middle, fail to grow together. Such a failure is a consequence of the abnormal migration and proliferation of facial embryonic tissues called mesenchyme. The defect occurs most often among Asians and certain Native American groups, less frequently among whites, and least often among African Americans.

Approximately 25% of infants born with cleft palate have inherited the trait from one or both parents. The cause for the other 75% remains unknown, but may be a combination of heredity, poor nutrition, use of drugs, or a disease the mother contracted while pregnant. Maternal smoking represents the most controversial association. The cleft may involve only the upper lip, may extend into the palate, or may be located on the back of the palate.

Surgery is especially important to correct the defect in the palate. Feeding a baby with cleft palate is difficult because the food can pass through the palate into the nasal cavity and may be inhaled and cause choking. In the newborn, whose bones have not completely hardened, surgery is relatively simple. As the child ages, however, surgical correction is more difficult and the child will require speech therapy.


Spina bifida

Spina bifida or open spine occurs once in 2,000 births in the United States. It belongs to a group of defects known as neural tube defects that are the second most prevalent neonatal anomaly in the United States after cardiac malformations. It occurs when the edges of the spine that should grow around the spinal cord do not meet. An open area remains, which can mean that an area of the spinal cord (or the entire spinal cord, in the most severe cases) are unprotected. The mildest form of spina bifida may be so slight that the defect does not have any effect on the child and is discovered by accident, usually when an x ray is taken for another reason. The term spinal bifida means the spine is cleft, having an opening or space, in two parts.

Spina bifida may present itself as a cyst, ranging in size from a walnut to a grapefruit, in which some parts of the meninges (layers of connective tissue covering the spinal cord), spinal cord, or both are contained. The lump can be removed surgically. In the most serious form, the lump or cyst has little skin or covering so spinal fluid may leak from it. Roots of the spinal nerves are contained within the cyst and the cyst may be covered with sores. Infection is a serious risk until surgery has been performed and the area has healed. Unfortunately, this condition may leave the child's legs partially or completely paralyzed and without feeling. Other associated problems may include control of the bowels and bladder.

Newborns with spina bifida often have an associated condition called hydrocephalus, which literally means water in the head. In this condition, cerebrospinal fluid collects in and around the brain and will not drain. Mental retardation can result if the fluid is not drained regularly. This can be accomplished by implanting a special tube (called a shunt) leading from the brain down into a vein in the child's neck or into the child's chest to allow the fluid to drain harmlessly. Hydrocephaly also can occur in infants who do not have spina bifida. The cause of spina bifida is not known, nor is any means of prevention. It can be diagnosed before birth by amniocentesis (by dosing the intra-amniotic alpha feto protein) or ultrasound. The risk of having a baby with spina bifida or other associated defects seems to be reduced if a woman takes at least 400 mg of folic acid just before and throughout pregnancy.


Heart defects

Congenital heart defects occur in one of every 115 births in the United States. The defect may be so mild that it is not detected for some years or it may be fatal. A baby with a heart defect may be born showing a bluish tinge around the lips and on the fingers. This condition, called cyanosis, is a signal that the body is not receiving enough oxygen. The blue color may disappear shortly after birth, indicating that all is normal, or it may persist, indicating that further testing is needed to determine the nature of the heart defect.

A normal heart has four chambers; two upper, called the atria (singular: atrium) and two lower called the ventricles. The right heart receives the blood that is returning from the body, and has been depleted of oxygen. This oxygen-poor blood arrives in the right atrium, where it is pumped into the right ventricle. The right ventricle sends oxygen-poor blood to the lungs, where it is exposed to and picks up plenty of oxygen again. This oxygen-rich blood enters the left atrium and is then pumped into the left ventricle. The left ventricle pumps oxygen-rich blood through the aorta to all the organs and tissues of the body.

During fetal development, blood circulation occurs differently, because the fetus' blood does not need to flow through its lungs. It receives its oxygen from the mother through the placenta via the umbilical cord. Since the atria communicate during fetal life, blood rich in oxygen coming from inferior vena cava crosses the foramen ovale and into the left atrium bypassing the lungs (eventually the foramen ovale is closed from the higher pressure generated at the left side after the lunds expand at birth). Another special shunt, the arterious duct connects the main pulmonary artery to the aorta. In such a way, the blood flow that does enter the right atrium enters the right ventricle, then the main pulmonary artery, then enters the ductus arteriosus which connects to the aorta. In this way the vast majority of blood flow bypasses the lungs during development of the fetus. Normally the shunts should close at birth. After birth, blood should begin to circulate through the lungs for the first time, because the newborn baby's lungs are now responsible for delivering oxygen to the blood. Sometimes, however, the shunt does not close properly, and blood is not appropriately circulated through the lungs. When this occurs, surgery is required to close the shunt and restore normal circulation.

If it is undetected at birth, a heart defect may impair the growth of a child. He will be unable to exert the energy that other children do at play because he cannot supply sufficient oxygen to his body. He may become breathless at small amounts of exertion and may squat frequently because it is easier to breathe in that position.

Some minor defects may disappear over time as the child grows. A small hole in the wall between the left and right sides of the heart, which causes symptoms by allowing the mixing of oxygen-poor and oxygen-rich blood, for example, may spontaneously close over time. A larger defect will require surgical patching.

Some newborns may have only one upper chamber or only a single lower chamber of the heart. The aorta, where it begins at the heart, may be narrowed (stenosed) and impair the flow of blood from the heart. Some of the heart valves may not function correctly and occasionally the vessels of the heart may be transposed so that the aorta leads from the right side of the heart, delivering oxygen-poor blood to the organs and tissues.

These are only a few of the heart anomalies that can be present in the newborn. The heart is a complicated organ and its formation can be influenced by hereditary factors as well as by alcohol consumption or smoking. Fortunately, most heart defects correct themselves over time or can be corrected with surgery.


Other physical deformities

Physical defects in newborns are common. They can affect any of the bones or muscles in the body and may or may not be correctable. Among the more common are the presence of extra fingers or toes (polydactyly), which presents no health threat and can be corrected surgically. Similarly, webbed fingers and toes, a genetic disorder, seen in approximately one of every 1,700 to 2,000 births, can be treated surgically to resemble a normal appendage.

A more serious, though relatively rare, condition is called achondroplasia; this term means without cartilage formation and refers to the supposed lack of cartilage growth plates near the ends of a child's bones. In fact, the plates are present, but grow poorly. Achondroplasia is a type of dwarfism. This genetic disorder of bone growth is seen in one in 20,000 births and is one of the oldest known birth defects. Ancient Egyptian art shows individuals with this condition.

The cause of achondroplasia is not known, nor is there a cure. The child who has this condition will be slow at walking and sitting because of his short arms and legs, and this may be interpreted as mental retardation. However, these individuals have normal intelligence.


In addition to physical deformities, certain diseases and syndromes also are passed to the infant through the parents' genes. Some of these conditions can be controlled or treated while others are untreatable and fatal.


Sickle cell anemia

Sickle cell anemia is an inherited disease of the blood cells that occurs in about one of every 400 African Americans. An individual can be a carrier of sickle cell anemia, in which case he or she has the gene but does not show any active signs of the disease. If two carriers become parents, however, some of their children may have sickle cell anemia.

The disease gets its name because certain red blood cells assume a sickle shape and lodge in small blood vessels. This altered shape is a function of the hemoglobin molecule present in red blood cells. Two forms of hemoglobin make up these cells: hemoglobin A (Hb A) and hemoglobin B (Hb B). In individuals with sickle cell anemia, Hb B is instead produced as Hb S, a form of hemoglobin with a rigid, sickle shape that deforms the red blood cell. When the cell becomes wedged in a small blood vessel it prevents the flow of blood through the vessel and can initiate what is called a sickle cell crisis. The lack of blood flow to the tissues being blocked causes pain and inflammation of the oxygen-deprived tissue.

Abnormal red blood cells are removed from the circulatory system by the spleen, but removal of large numbers of such cells can lead to anemia, a lack of adequate numbers red blood cells. Unfortunately, the breakdown of abnormal red blood cells can in itself cause a serious condition in which excess iron, scavenged from the hemoglobin molecule, is deposited in tissues such as the heart and liver. So, although replacement of the destroyed red blood cells could be achieved with blood transfusion, the replacement cells will only add to the iron content of blood. There is no cure for sickle cell anemia, though scientists are learning how to better control it to prevent sickling of the blood cells.


Tay-Sachs disease

Tay-Sachs disease affects Jews of eastern European origin, the Ashkenazi Jews, and is a condition that is fatal at an early age. A carrier of the disease will have a gene for Tay-Sachs disease and another gene that is normal. If two carriers have children, every pregnancy will have a 25% chance of producing a completely normal child; a 50% chance of producing a child who will carry the trait, but reveal no symptoms; and a 25% chance of producing a child who actually suffers from the disease.

The newborn Tay-Sachs child lacks a blood enzyme called hexosaminidase A, which breaks down certain fats in the brain and nerve cells. When first born, the baby appears totally normal. However, over a short period of time, the brain cells become clogged with fatty deposits, and the child begins to lose functioning. As the disease progresses, the child will no longer be able to smile, crawl, or turn over, and will ultimately become blind and unaware of his surroundings. Usually the child dies by the age of three or four years.

There is currently no cure for Tay-Sachs disease, although carriers can be detected by a simple blood test that measures the amount of hexosaminidase A. A carrier will have half the amount of the enzyme as a normal person, and two carriers can be counseled to explain the probability of producing an offspring with Tay-Sachs disease. Researchers are trying to find a way to provide sufficient levels of the missing enzyme in the newborn, or to find a suitable substitute that could be supplied as the child ages, much like insulin is used to treat diabetes. A more technologically advanced line of research is examining the possibility of transplanting a normal gene to replace the defective one in carriers.

Down syndrome

One in every 800-1,000 babies is born with Down syndrome. Down syndrome babies may have eyes that slant upward, small ears that may turn over at the top, a small mouth and nose that also is flattened between the eyes (at the bridge). Mental retardation is present in varying degrees, but most Down's syndrome children have only mild to moderate retardation. Generally these children walk, talk, dress themselves, and are toilet trained later than children with normal intelligence.

Down syndrome results when either the egg or the sperm that fertilizes it has an extra chromosome. Normally a human has 23 pairs of chromosomes, for a total of 46. An extra chromosome, specifically an extra number 21 chromosome, present when the egg is fertilized, leads to a baby with Down syndrome. Of course, if either parent has Down syndrome, the probability of passing the condition on to the offspring is increased. Also, parents who have had one Down syndrome child and mothers older than 35 years of age are at increased risk of having a Down syndrome baby. There is no cure, though many of these children can go on to attend school and hold jobs as do unaffected individuals.

It should be apparent from this small sample, that some birth defects are hereditary, passed from parents to offspring; little can now be done to prevent or cure these conditions, but genetic therapy offers hope that this situation may change in the future. Other birth defects result from infections of the mother during pregnancy, or from maternal consumption of alcohol or drugs, use of tobacco, or exposure to radiation or chemicals during pregnancy. In some cases, these birth defects can be prevented through education or improved prenatal care.

Resources

Books

Nussbaum, R.L., Roderick R. McInnes, Huntington F. Willard. Genetics in Medicine. Philadelphia: Saunders, 2001.

Rimoin, D.L. Emery and Rimoin's Principles and Practice of Medical Genetics. London; New York: Churchill Livingstone, 2002.

Sadler, T.W. and Jan Langman. Langman's Medical Embryology,, 8th ed. Lippincott Williams & Wilkins Publishers, 2000.


Larry Blaser

KEY TERMS

. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Hemoglobin

—The substance within red blood cells that gives blood its characteristic red color and carries oxygen to the cells of the body.

In utero

—While in the uterus, prior to birth.

Placenta

—The flat, plate-like organ of exchange between the blood of the mother and that of the embryo. It attaches to the wall of the uterus and provides nutrients and oxygen for the embryo and removes wastes from the embryo.

[back] Birth - Viviparous Animals, Maternal Progesterone, Oxytocin, History Of Childbirth, Types Of Childbirth Preparation, Types Of Anesthesia - How does birth begin?, Fetal endocrine control, Birth in humans

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about 4 years ago

My husband died in 2004 suffering from Von Hipple Lindou Syndrome, his sister, same Mother & Father, is 59 years of age and has Apert's Syndrome. I am trying to find out how this could have happened, I have read that this is possibly a Sperm fault from Father-in-law, he was working in Coventry durig WW2.

Where do I even start looking?

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about 1 month ago

Fate line of palm print indicating an adaptability as discontinuous split genes become continuous

Sankaravelayudhan Nandakumar Nandakumar
10:24 AM (22 hours ago)


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genes could be discontinuous, that is, a given gene could be present in the genetic material (DNA) as several, well-separated segments. As their experimental model system, both Roberts and Sharp used a common cold-causing virus, called adenovirus, whose genes display important similarities to those in higher organisms. Shortly thereafter it could be shown by several researchers that split genes are frequent in higher organisms, including man.
In biochemical experiments it was shown that one end of an adenovirus messenger RNA did not behave as expected. One of several possible explanations was that the DNA segment corresponding to this end was not located in the immediate vicinity of the rest of the gene. To determine where this segment was located on the long DNA molecule, they used electron microscopy. They surprisingly found that a single RNA molecule corresponded to no less than four well-separated segments in the DNA molecule.
A gene may thus consist of several segments, usually termed exons separated by intervening DNA, termed introns. This knowledge has radically changed our view on how the genetic material has developed during the course of evolution. It has long been considered likely that evolution takes place as the result of the accumulation of minor alterations in the genetic material (mutations) resulting in a gradual change.
A fate line of palm print in a way decides its deviations as discontinuites and continuities.
As a consequence of the discovery that genes are often split, it seems likely that higher organisms in addition to undergoing mutations may utilize another mechanism to speed up evolution: rearrangement (or shuffling) of gene segments to new functional units. This can take place in the germ cells through crossing-over during pairing of chromosomes. This hypothesis seems even more attractive following the discovery that individual exons in several cases correspond to building modules in proteins, so-called domains, to which specific functions can be attributed. An exon in the genome would thus correspond to a particular subfunction in the protein and the rearrangement of exons could result in a new combination of subfunctions in a protein. This kind of process could drive evolution considerably by rearranging modules with specific functions.
Islanded formation at the end of lifeline in palm print indicating cancer

Sankaravelayudhan Nandakumar Nandakumar
10:08 AM (23 hours ago)


to proceedingsa, feedback



Inside the nucleus of a cell, our genes are arranged along twisted, double-stranded molecules of DNA called chromosomes. At the ends of the chromosomes are stretches of DNA called telomeres, which protect our genetic data, make it possible for cells to divide, and hold some secrets to how we age and get cancer.
Telomeres have been compared with the plastic tips on shoelaces, because they keep chromosome ends from fraying and sticking to each other, which would destroy or scramble an organism's genetic information.
Yet, each time a cell divides, the telomeres get shorter. When they get too short, the cell can no longer divide; it becomes inactive or "senescent" or it dies. This shortening process is associated with aging, cancer, and a higher risk of death. So telomeres also have been compared with a bomb fuse.
Without telomeres, the main part of the chromosome — the part with genes essential for life — would get shorter each time a cell divides. So telomeres allow cells to divide without losing genes. Cell division is necessary for growing new skin, blood, bone, and other cells.
Without telomeres, chromosome ends could fuse together and corrupt the cell's genetic blueprint, possibly causing malfunction, cancer, or cell death. Because broken DNA is dangerous, a cell has the ability to sense and repair chromosome damage. Without telomeres, the ends of chromosomes would look like broken DNA, and the cell would try to fix something that wasn't broken. That also would make them stop dividing and eventually die.
Before a cell can divide, it makes copies of its chromosomes so that both new cells will have identical genetic material. To be copied, a chromosome's two DNA strands must unwind and separate. An enzyme (DNA polymerase) then reads the existing strands to build two new strands. It begins the process with the help of short pieces of RNA. When each new matching strand is complete, it is a bit shorter than the original strand because of the room needed at the end for this small piece of RNA. It is like someone who paints himself into a corner and cannot paint the corner.

If a cell begins to become cancerous, it divides more often, and its telomeres become very short. If its telomeres get too short, the cell may die. Often times, these cells escape death by making more telomerase enzyme, which prevents the telomeres from getting even shorter.
Many cancers have shortened telomeres, including pancreatic, bone, prostate, bladder, lung, kidney, and head and neck.
Measuring telomerase may be a way to detect cancer. And if scientists can learn how to stop telomerase, they might be able to fight cancer by making cancer cells age and die. In one experiment, researchers blocked telomerase activity in human breast and prostate cancer cells growing in the laboratory, prompting the tumor cells to die. But there are risks. Blocking telomerase could impair fertility, wound healing, and production of blood cells and immune system cell

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about 1 month ago

Fate line of palm print indicating an adaptability as discontinuous split genes become continuous

Sankaravelayudhan Nandakumar Nandakumar
10:24 AM (22 hours ago)


to proceedingsa, feedback



genes could be discontinuous, that is, a given gene could be present in the genetic material (DNA) as several, well-separated segments. As their experimental model system, both Roberts and Sharp used a common cold-causing virus, called adenovirus, whose genes display important similarities to those in higher organisms. Shortly thereafter it could be shown by several researchers that split genes are frequent in higher organisms, including man.
In biochemical experiments it was shown that one end of an adenovirus messenger RNA did not behave as expected. One of several possible explanations was that the DNA segment corresponding to this end was not located in the immediate vicinity of the rest of the gene. To determine where this segment was located on the long DNA molecule, they used electron microscopy. They surprisingly found that a single RNA molecule corresponded to no less than four well-separated segments in the DNA molecule.
A gene may thus consist of several segments, usually termed exons separated by intervening DNA, termed introns. This knowledge has radically changed our view on how the genetic material has developed during the course of evolution. It has long been considered likely that evolution takes place as the result of the accumulation of minor alterations in the genetic material (mutations) resulting in a gradual change.
A fate line of palm print in a way decides its deviations as discontinuites and continuities.
As a consequence of the discovery that genes are often split, it seems likely that higher organisms in addition to undergoing mutations may utilize another mechanism to speed up evolution: rearrangement (or shuffling) of gene segments to new functional units. This can take place in the germ cells through crossing-over during pairing of chromosomes. This hypothesis seems even more attractive following the discovery that individual exons in several cases correspond to building modules in proteins, so-called domains, to which specific functions can be attributed. An exon in the genome would thus correspond to a particular subfunction in the protein and the rearrangement of exons could result in a new combination of subfunctions in a protein. This kind of process could drive evolution considerably by rearranging modules with specific functions.
Islanded formation at the end of lifeline in palm print indicating cancer

Sankaravelayudhan Nandakumar Nandakumar
10:08 AM (23 hours ago)


to proceedingsa, feedback



Inside the nucleus of a cell, our genes are arranged along twisted, double-stranded molecules of DNA called chromosomes. At the ends of the chromosomes are stretches of DNA called telomeres, which protect our genetic data, make it possible for cells to divide, and hold some secrets to how we age and get cancer.
Telomeres have been compared with the plastic tips on shoelaces, because they keep chromosome ends from fraying and sticking to each other, which would destroy or scramble an organism's genetic information.
Yet, each time a cell divides, the telomeres get shorter. When they get too short, the cell can no longer divide; it becomes inactive or "senescent" or it dies. This shortening process is associated with aging, cancer, and a higher risk of death. So telomeres also have been compared with a bomb fuse.
Without telomeres, the main part of the chromosome — the part with genes essential for life — would get shorter each time a cell divides. So telomeres allow cells to divide without losing genes. Cell division is necessary for growing new skin, blood, bone, and other cells.
Without telomeres, chromosome ends could fuse together and corrupt the cell's genetic blueprint, possibly causing malfunction, cancer, or cell death. Because broken DNA is dangerous, a cell has the ability to sense and repair chromosome damage. Without telomeres, the ends of chromosomes would look like broken DNA, and the cell would try to fix something that wasn't broken. That also would make them stop dividing and eventually die.
Before a cell can divide, it makes copies of its chromosomes so that both new cells will have identical genetic material. To be copied, a chromosome's two DNA strands must unwind and separate. An enzyme (DNA polymerase) then reads the existing strands to build two new strands. It begins the process with the help of short pieces of RNA. When each new matching strand is complete, it is a bit shorter than the original strand because of the room needed at the end for this small piece of RNA. It is like someone who paints himself into a corner and cannot paint the corner.

If a cell begins to become cancerous, it divides more often, and its telomeres become very short. If its telomeres get too short, the cell may die. Often times, these cells escape death by making more telomerase enzyme, which prevents the telomeres from getting even shorter.
Many cancers have shortened telomeres, including pancreatic, bone, prostate, bladder, lung, kidney, and head and neck.
Measuring telomerase may be a way to detect cancer. And if scientists can learn how to stop telomerase, they might be able to fight cancer by making cancer cells age and die. In one experiment, researchers blocked telomerase activity in human breast and prostate cancer cells growing in the laboratory, prompting the tumor cells to die. But there are risks. Blocking telomerase could impair fertility, wound healing, and production of blood cells and immune system cell

Vote down Vote up

about 1 month ago

Fate line of palm print indicating an adaptability as discontinuous split genes become continuous

Sankaravelayudhan Nandakumar Nandakumar
10:24 AM (22 hours ago)


to proceedingsa, feedback



genes could be discontinuous, that is, a given gene could be present in the genetic material (DNA) as several, well-separated segments. As their experimental model system, both Roberts and Sharp used a common cold-causing virus, called adenovirus, whose genes display important similarities to those in higher organisms. Shortly thereafter it could be shown by several researchers that split genes are frequent in higher organisms, including man.
In biochemical experiments it was shown that one end of an adenovirus messenger RNA did not behave as expected. One of several possible explanations was that the DNA segment corresponding to this end was not located in the immediate vicinity of the rest of the gene. To determine where this segment was located on the long DNA molecule, they used electron microscopy. They surprisingly found that a single RNA molecule corresponded to no less than four well-separated segments in the DNA molecule.
A gene may thus consist of several segments, usually termed exons separated by intervening DNA, termed introns. This knowledge has radically changed our view on how the genetic material has developed during the course of evolution. It has long been considered likely that evolution takes place as the result of the accumulation of minor alterations in the genetic material (mutations) resulting in a gradual change.
A fate line of palm print in a way decides its deviations as discontinuites and continuities.
As a consequence of the discovery that genes are often split, it seems likely that higher organisms in addition to undergoing mutations may utilize another mechanism to speed up evolution: rearrangement (or shuffling) of gene segments to new functional units. This can take place in the germ cells through crossing-over during pairing of chromosomes. This hypothesis seems even more attractive following the discovery that individual exons in several cases correspond to building modules in proteins, so-called domains, to which specific functions can be attributed. An exon in the genome would thus correspond to a particular subfunction in the protein and the rearrangement of exons could result in a new combination of subfunctions in a protein. This kind of process could drive evolution considerably by rearranging modules with specific functions.
Islanded formation at the end of lifeline in palm print indicating cancer

Sankaravelayudhan Nandakumar Nandakumar
10:08 AM (23 hours ago)


to proceedingsa, feedback



Inside the nucleus of a cell, our genes are arranged along twisted, double-stranded molecules of DNA called chromosomes. At the ends of the chromosomes are stretches of DNA called telomeres, which protect our genetic data, make it possible for cells to divide, and hold some secrets to how we age and get cancer.
Telomeres have been compared with the plastic tips on shoelaces, because they keep chromosome ends from fraying and sticking to each other, which would destroy or scramble an organism's genetic information.
Yet, each time a cell divides, the telomeres get shorter. When they get too short, the cell can no longer divide; it becomes inactive or "senescent" or it dies. This shortening process is associated with aging, cancer, and a higher risk of death. So telomeres also have been compared with a bomb fuse.
Without telomeres, the main part of the chromosome — the part with genes essential for life — would get shorter each time a cell divides. So telomeres allow cells to divide without losing genes. Cell division is necessary for growing new skin, blood, bone, and other cells.
Without telomeres, chromosome ends could fuse together and corrupt the cell's genetic blueprint, possibly causing malfunction, cancer, or cell death. Because broken DNA is dangerous, a cell has the ability to sense and repair chromosome damage. Without telomeres, the ends of chromosomes would look like broken DNA, and the cell would try to fix something that wasn't broken. That also would make them stop dividing and eventually die.
Before a cell can divide, it makes copies of its chromosomes so that both new cells will have identical genetic material. To be copied, a chromosome's two DNA strands must unwind and separate. An enzyme (DNA polymerase) then reads the existing strands to build two new strands. It begins the process with the help of short pieces of RNA. When each new matching strand is complete, it is a bit shorter than the original strand because of the room needed at the end for this small piece of RNA. It is like someone who paints himself into a corner and cannot paint the corner.

If a cell begins to become cancerous, it divides more often, and its telomeres become very short. If its telomeres get too short, the cell may die. Often times, these cells escape death by making more telomerase enzyme, which prevents the telomeres from getting even shorter.
Many cancers have shortened telomeres, including pancreatic, bone, prostate, bladder, lung, kidney, and head and neck.
Measuring telomerase may be a way to detect cancer. And if scientists can learn how to stop telomerase, they might be able to fight cancer by making cancer cells age and die. In one experiment, researchers blocked telomerase activity in human breast and prostate cancer cells growing in the laboratory, prompting the tumor cells to die. But there are risks. Blocking telomerase could impair fertility, wound healing, and production of blood cells and immune system cell

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about 1 month ago

Fate line of palm print indicating an adaptability as discontinuous split genes become continuous

Sankaravelayudhan Nandakumar Nandakumar
10:24 AM (22 hours ago)


to proceedingsa, feedback



genes could be discontinuous, that is, a given gene could be present in the genetic material (DNA) as several, well-separated segments. As their experimental model system, both Roberts and Sharp used a common cold-causing virus, called adenovirus, whose genes display important similarities to those in higher organisms. Shortly thereafter it could be shown by several researchers that split genes are frequent in higher organisms, including man.
In biochemical experiments it was shown that one end of an adenovirus messenger RNA did not behave as expected. One of several possible explanations was that the DNA segment corresponding to this end was not located in the immediate vicinity of the rest of the gene. To determine where this segment was located on the long DNA molecule, they used electron microscopy. They surprisingly found that a single RNA molecule corresponded to no less than four well-separated segments in the DNA molecule.
A gene may thus consist of several segments, usually termed exons separated by intervening DNA, termed introns. This knowledge has radically changed our view on how the genetic material has developed during the course of evolution. It has long been considered likely that evolution takes place as the result of the accumulation of minor alterations in the genetic material (mutations) resulting in a gradual change.
A fate line of palm print in a way decides its deviations as discontinuites and continuities.
As a consequence of the discovery that genes are often split, it seems likely that higher organisms in addition to undergoing mutations may utilize another mechanism to speed up evolution: rearrangement (or shuffling) of gene segments to new functional units. This can take place in the germ cells through crossing-over during pairing of chromosomes. This hypothesis seems even more attractive following the discovery that individual exons in several cases correspond to building modules in proteins, so-called domains, to which specific functions can be attributed. An exon in the genome would thus correspond to a particular subfunction in the protein and the rearrangement of exons could result in a new combination of subfunctions in a protein. This kind of process could drive evolution considerably by rearranging modules with specific functions.
Islanded formation at the end of lifeline in palm print indicating cancer

Sankaravelayudhan Nandakumar Nandakumar
10:08 AM (23 hours ago)


to proceedingsa, feedback



Inside the nucleus of a cell, our genes are arranged along twisted, double-stranded molecules of DNA called chromosomes. At the ends of the chromosomes are stretches of DNA called telomeres, which protect our genetic data, make it possible for cells to divide, and hold some secrets to how we age and get cancer.
Telomeres have been compared with the plastic tips on shoelaces, because they keep chromosome ends from fraying and sticking to each other, which would destroy or scramble an organism's genetic information.
Yet, each time a cell divides, the telomeres get shorter. When they get too short, the cell can no longer divide; it becomes inactive or "senescent" or it dies. This shortening process is associated with aging, cancer, and a higher risk of death. So telomeres also have been compared with a bomb fuse.
Without telomeres, the main part of the chromosome — the part with genes essential for life — would get shorter each time a cell divides. So telomeres allow cells to divide without losing genes. Cell division is necessary for growing new skin, blood, bone, and other cells.
Without telomeres, chromosome ends could fuse together and corrupt the cell's genetic blueprint, possibly causing malfunction, cancer, or cell death. Because broken DNA is dangerous, a cell has the ability to sense and repair chromosome damage. Without telomeres, the ends of chromosomes would look like broken DNA, and the cell would try to fix something that wasn't broken. That also would make them stop dividing and eventually die.
Before a cell can divide, it makes copies of its chromosomes so that both new cells will have identical genetic material. To be copied, a chromosome's two DNA strands must unwind and separate. An enzyme (DNA polymerase) then reads the existing strands to build two new strands. It begins the process with the help of short pieces of RNA. When each new matching strand is complete, it is a bit shorter than the original strand because of the room needed at the end for this small piece of RNA. It is like someone who paints himself into a corner and cannot paint the corner.

If a cell begins to become cancerous, it divides more often, and its telomeres become very short. If its telomeres get too short, the cell may die. Often times, these cells escape death by making more telomerase enzyme, which prevents the telomeres from getting even shorter.
Many cancers have shortened telomeres, including pancreatic, bone, prostate, bladder, lung, kidney, and head and neck.
Measuring telomerase may be a way to detect cancer. And if scientists can learn how to stop telomerase, they might be able to fight cancer by making cancer cells age and die. In one experiment, researchers blocked telomerase activity in human breast and prostate cancer cells growing in the laboratory, prompting the tumor cells to die. But there are risks. Blocking telomerase could impair fertility, wound healing, and production of blood cells and immune system cell

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about 1 month ago

Fate line of palm print indicating an adaptability as discontinuous split genes become continuous

Sankaravelayudhan Nandakumar Nandakumar
10:24 AM (22 hours ago)


to proceedingsa, feedback



genes could be discontinuous, that is, a given gene could be present in the genetic material (DNA) as several, well-separated segments. As their experimental model system, both Roberts and Sharp used a common cold-causing virus, called adenovirus, whose genes display important similarities to those in higher organisms. Shortly thereafter it could be shown by several researchers that split genes are frequent in higher organisms, including man.
In biochemical experiments it was shown that one end of an adenovirus messenger RNA did not behave as expected. One of several possible explanations was that the DNA segment corresponding to this end was not located in the immediate vicinity of the rest of the gene. To determine where this segment was located on the long DNA molecule, they used electron microscopy. They surprisingly found that a single RNA molecule corresponded to no less than four well-separated segments in the DNA molecule.
A gene may thus consist of several segments, usually termed exons separated by intervening DNA, termed introns. This knowledge has radically changed our view on how the genetic material has developed during the course of evolution. It has long been considered likely that evolution takes place as the result of the accumulation of minor alterations in the genetic material (mutations) resulting in a gradual change.
A fate line of palm print in a way decides its deviations as discontinuites and continuities.
As a consequence of the discovery that genes are often split, it seems likely that higher organisms in addition to undergoing mutations may utilize another mechanism to speed up evolution: rearrangement (or shuffling) of gene segments to new functional units. This can take place in the germ cells through crossing-over during pairing of chromosomes. This hypothesis seems even more attractive following the discovery that individual exons in several cases correspond to building modules in proteins, so-called domains, to which specific functions can be attributed. An exon in the genome would thus correspond to a particular subfunction in the protein and the rearrangement of exons could result in a new combination of subfunctions in a protein. This kind of process could drive evolution considerably by rearranging modules with specific functions.
Islanded formation at the end of lifeline in palm print indicating cancer

Sankaravelayudhan Nandakumar Nandakumar
10:08 AM (23 hours ago)


to proceedingsa, feedback



Inside the nucleus of a cell, our genes are arranged along twisted, double-stranded molecules of DNA called chromosomes. At the ends of the chromosomes are stretches of DNA called telomeres, which protect our genetic data, make it possible for cells to divide, and hold some secrets to how we age and get cancer.
Telomeres have been compared with the plastic tips on shoelaces, because they keep chromosome ends from fraying and sticking to each other, which would destroy or scramble an organism's genetic information.
Yet, each time a cell divides, the telomeres get shorter. When they get too short, the cell can no longer divide; it becomes inactive or "senescent" or it dies. This shortening process is associated with aging, cancer, and a higher risk of death. So telomeres also have been compared with a bomb fuse.
Without telomeres, the main part of the chromosome — the part with genes essential for life — would get shorter each time a cell divides. So telomeres allow cells to divide without losing genes. Cell division is necessary for growing new skin, blood, bone, and other cells.
Without telomeres, chromosome ends could fuse together and corrupt the cell's genetic blueprint, possibly causing malfunction, cancer, or cell death. Because broken DNA is dangerous, a cell has the ability to sense and repair chromosome damage. Without telomeres, the ends of chromosomes would look like broken DNA, and the cell would try to fix something that wasn't broken. That also would make them stop dividing and eventually die.
Before a cell can divide, it makes copies of its chromosomes so that both new cells will have identical genetic material. To be copied, a chromosome's two DNA strands must unwind and separate. An enzyme (DNA polymerase) then reads the existing strands to build two new strands. It begins the process with the help of short pieces of RNA. When each new matching strand is complete, it is a bit shorter than the original strand because of the room needed at the end for this small piece of RNA. It is like someone who paints himself into a corner and cannot paint the corner.

If a cell begins to become cancerous, it divides more often, and its telomeres become very short. If its telomeres get too short, the cell may die. Often times, these cells escape death by making more telomerase enzyme, which prevents the telomeres from getting even shorter.
Many cancers have shortened telomeres, including pancreatic, bone, prostate, bladder, lung, kidney, and head and neck.
Measuring telomerase may be a way to detect cancer. And if scientists can learn how to stop telomerase, they might be able to fight cancer by making cancer cells age and die. In one experiment, researchers blocked telomerase activity in human breast and prostate cancer cells growing in the laboratory, prompting the tumor cells to die. But there are risks. Blocking telomerase could impair fertility, wound healing, and production of blood cells and immune system cell

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about 1 month ago

Break in the life line and fate line indicating genetic reversibility-reg

Sankaravelayudhan Nandakumar Nandakumar
10:15 AM (0 minutes ago)


to mpepe



Respected Pepe,will you be interested in Astrogenetic implications?
Margaret Pepe
Research focus: Dr. Pepe’s areas of research include evaluation of tests and biomarkers for disease screening, diagnosis, prognosis and risk prediction. I
Breaking life line involved in Immuno resistivity failure,insulin injection failure in Pancreas,when life line cutting through lifeline with islanded formation indicating cancer etc.
Breaks denote unpleasant interruption in the progress of one’s life, generally indicate a defective condition. A break, especially leaving an unoccupied space lengthwise between the two fragments -as described in the picture - denotes serious and alarming outcome than the one where repairing or overlaying is present. Here, break cannot indicate death, but, the person must be warned of some kind of serious consumption is taking place in his/her body. If all other things are normal, generally, I take it as poor digestion system. He will survive even if he faces a severe heart attack, but, if the life line takes a hook shape at the break than the break indicates survival would be very difficult and the incident can lead to death. You can advise him to 'go slow' and to visit his GP.
Break in the life line and fate line:
Go for medical diagnosis well in advance
A long and well defined life line indicates physical strength character, and vitality of determination. It predicts a long and meaningful life.
If it is chained or islanded at the very start, it indicates early life upper part of the body is subjected to more problems.
Large break/gap (half inch long) on both life lines about one inch from the bottom.
We do have degenerative disc disease (arthritis) in the lumbar region. In addition, at about 40 years old, I developed anxiety/panic attacks and chronic low grade depression which plagued for many years.
I have a friend who is left handed and have a similar break in his right hand only. He has a herniated disc in the Lumbar area and alcohol problems but quite a successful businessman.
Here, break cannot indicate death, but, the person must be warned of some kind of serious consumption is taking place in his/her body. If all other things are normal, generally, I take it as poor digestion system. Possibility of Pancreas problem fail to inject insulin is also indicated
Ref:A doctors guide to "Better health through palmistry" by Eugene Scheiman M.D.
Kindly give me a feedback,Encourage me
Sankaravelyudhan Nandakumar,Oxford astrogeneticist,Hubble telescope verification scholar
Fred Hutchinson Cancer Research Center
1100 Fairview Ave. N., PO Box 19024, Seattle, WA 98109
© 2014 Fred Hutchinson Cancer Research Center, a 501(c)(3) nonprofit organ

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about 1 month ago

Break in the life line and fate line indicating genetic reversibility-reg

Sankaravelayudhan Nandakumar Nandakumar
10:15 AM (0 minutes ago)


to mpepe



Respected Pepe,will you be interested in Astrogenetic implications?
Margaret Pepe
Research focus: Dr. Pepe’s areas of research include evaluation of tests and biomarkers for disease screening, diagnosis, prognosis and risk prediction. I
Breaking life line involved in Immuno resistivity failure,insulin injection failure in Pancreas,when life line cutting through lifeline with islanded formation indicating cancer etc.
Breaks denote unpleasant interruption in the progress of one’s life, generally indicate a defective condition. A break, especially leaving an unoccupied space lengthwise between the two fragments -as described in the picture - denotes serious and alarming outcome than the one where repairing or overlaying is present. Here, break cannot indicate death, but, the person must be warned of some kind of serious consumption is taking place in his/her body. If all other things are normal, generally, I take it as poor digestion system. He will survive even if he faces a severe heart attack, but, if the life line takes a hook shape at the break than the break indicates survival would be very difficult and the incident can lead to death. You can advise him to 'go slow' and to visit his GP.
Break in the life line and fate line:
Go for medical diagnosis well in advance
A long and well defined life line indicates physical strength character, and vitality of determination. It predicts a long and meaningful life.
If it is chained or islanded at the very start, it indicates early life upper part of the body is subjected to more problems.
Large break/gap (half inch long) on both life lines about one inch from the bottom.
We do have degenerative disc disease (arthritis) in the lumbar region. In addition, at about 40 years old, I developed anxiety/panic attacks and chronic low grade depression which plagued for many years.
I have a friend who is left handed and have a similar break in his right hand only. He has a herniated disc in the Lumbar area and alcohol problems but quite a successful businessman.
Here, break cannot indicate death, but, the person must be warned of some kind of serious consumption is taking place in his/her body. If all other things are normal, generally, I take it as poor digestion system. Possibility of Pancreas problem fail to inject insulin is also indicated
Ref:A doctors guide to "Better health through palmistry" by Eugene Scheiman M.D.
Kindly give me a feedback,Encourage me
Sankaravelyudhan Nandakumar,Oxford astrogeneticist,Hubble telescope verification scholar
Fred Hutchinson Cancer Research Center
1100 Fairview Ave. N., PO Box 19024, Seattle, WA 98109
© 2014 Fred Hutchinson Cancer Research Center, a 501(c)(3) nonprofit organ

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9 months ago

I was born unable to open my hands palm side up, can you tell me what this is called?

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11 months ago

Tractor bessel beam with invisible clocking dynamics may be used to correct the Tole mere as capacity twister for DNA correction

Sankaravelayudhan Nandakumar Nandakumar
9:10 AM (0 minutes ago)


to news, j.pendry, Ada, s.w.hawking



Tractor wave in laser biostimulation may be used for genetic corrections using invisible cloaking dynamics combinations.
Three twisted supercapacitors connected in series could be used toto manipulate a invisible cloaking dynamics says Sankaravelyudhan Nandakumr in addition to tractor bessel beam connected genetic ATGU language may be used to correct a genetic defect as observed in the palm print at the meeting point of health line with life line.

An information available from Bossonova twisters may be utilised in all electronic super computers Bossonova twisters can be pushed up or down and this information could be utilise in Aerospace vehicles .The Electron by cross polarisation will act as twister by magnetic or electric field twisting may act as a capacitor says Sankaravelayudhan Nandakumar.They are really optical rogue waves by funnelling at the middle and sometimes at extereme domains for future merger and this could be utilise in our quantum entaglement teleportation in future.Electrons , pinned. as actually when an electron can behave like a sort of wave in the solid, but only an electron can stop an electron by their mutual interaction—their motion is almost freezed out. That is the essence of correlated electrons. The team was motivated by recent theoretical work which suggested that the behaviour of magnetic monopoles in momentum space is closely related to the anomalous Hall effect.This information will be utilised as extreme inductance algorithm as purely magnetic field as purely capacitive as electricfield monopoles as threseems to be shift by the mode of electron scattering such as a spirality as well as that of reflective dipole polaritons separations.digital 0,1 SQUAD applications.

Applying a magnetic field to a magnetic vortex pushes the vortex away from the center of the disk towards the frame. If one then turns the field off abruptly, the vortex moves either clockwise or counter clockwise on a spiral like trajectory back into its initial position in the center of the disk. This special movement is called gyration. In principal, the perpendicular magnetization of the vortex core can point either upwards or downwards, and four different kinds of movement can be found: right- and left rotating magnetic swirls, combined either with an up- or downward directed perpendicular core magnetization.Super conductive materials repel magneticfield when spin oposite directions and attract when spin in the same directions which becomes the beautiful nano digital circuit.At the quantum level, the forces of magnetism and superconductivity exist in an uneasy relationship. Superconducting materials repel a magnetic field, so to create a superconducting current, the magnetic forces must be strong enough to overcome the natural repulsion and penetrate the body of the superconductor. But there's a limit: Apply too much magnetic force, and the superconductor's capability is destroyed
When a magnetic field is applied to a superconducting material, vortices measured in nanometers (1 billionth of a meter) pop up. These vortices, like super-miniature tornadoes, are areas where the magnetic field has overpowered the superconducting field state, essentially suppressing it. Crank up the magnetic field and more vortices appear. At some point, the vortices are so widespread the material loses its superconducting ability altogether.But at critical stoke anstoke resonance on electron pairing at middle cross overs are amplified which seems to be an important finding.Normally the magnetic field is zero at this point ,but sometimes this theory is broken.There seems to be a converging diverging magneticfield that resonante for such cross overs along gliding the waves fluctuated under certain cross over conditions, but when more magnetic energy is added, the fluctuations disappear and the waves resume their repeating, linear patterns.There seems to be linaer to nonlinaer dynamics at the middle point.Hence, our experts consider them as potential candidates for future non volatile magnetic memories.
Bossonova dynamics deals with frequency shifts at microlevel nanotechnology at electron triplets.
Experiments Unraveled Dynamic Core Movements Of Magnetic Swirls:Skew scattering related hopping observed at spin up and spin down cross resonance seems to be a very interesting phenomena - The spin polarization S( theta) n induced by the skew scattering due to the spin-orbit interaction of the scatterer and the spin unpolarized electron beam for polarization
In March 2011, Chinese scientists posited that a specific type of Bessel beam (a special kind of laser that that does not diffract at the centre) is capable of creating a pull-like effect on a given microscopic particle, forcing it towards the beam source.[31][32] The underlining physics is the maximization of forward scattering via interference of the radiation multipoles. They show explicitly that the necessary condition to realize a negative (pulling) optical force is the simultaneous excitation of multipoles in the particle and if the projection of the total photon momentum along the propagation direction is small, attractive optical force is possible.[33] The Chinese scientists suggest this possibility may be implemented for optical micromanipulation.
Applying a magnetic field to a magnetic vortex pushes the vortex away from the center of the disk towards the frame. If one then turns the field off abruptly, the vortex moves either clockwise or counter clockwise on a spiral like trajectory back into its initial position in the center of the disk. This special movement is called gyration. In principal, the perpendicular magnetization of the vortex core can point either upwards or downwards, and four different kinds of movement can be found: right- and left rotating magnetic swirls, combined either with an up- or downward directed perpendicular core magnetization.
Sankaravelyudhan Nandakumar ,Astro geneticist
thomas.steitz@yale.edu
Sankaravelyudhan Nandakumar,Hubble research scholar http://www.hawking.org.uk
info@crick.ac.uk

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over 2 years ago

I was born unable to straiten my arms all the way and I don't know how this could of happend ive never heard of it before and I don't know what its called??

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over 2 years ago

I HAVE JUST HEARD DEFORMED BABIES CAN BE BORN, WHEN A CERTAIN AMOUNT OF TIME HAS NOT PASSED AFTER COMING OFF THE PILL. iS THIS TRUE?

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almost 3 years ago

Genetic abnormality observed as clubbed thumbed man in case of in case of Dr.Henry Meyer The trial of Dr. Henry Meyer, accused of killing Gustav Baum fey poison, with antimony and arsenic was finally begun yesterday before Recorder Smyth, after ten days consumed.Dr.Meyer was regularly graduated as Homeopathic physician in Chicago in 1898 In getting a jury. Assistant District Attorney McIntyre opened the case for the people as soon as court was called to order. Two writers of sensational detective stories were in attendance yesterday at the murder trial of Dr. Henry C.W. Meyer to gather material for their peculiar romances, and from present indications they will be well rewarded for their trouble. A more remarkable story of crime and its ferreting out has never been told in any courtroom.
With the help of Ludwig Brandt an agent for Mutual benefit life insurance association .Meyer was the medical examiner of this association and because of some fraudulent applications both were in jail during 1890 which ended with conspiracy and murder of Brandt. In fact Meyer married his own wife to Brandt for such a conspiracy.

Citation: Thumb radiation by spiral squeezing may compress and shorten and the gap may be reduced during any cancerous growth which may be an indication requiring scanning says Sankaravelayudhan Nandakumar,oxford Astrogeneticist ,Hubble research space science scholar. The spiral compression and expansion in thumb vortex requiring an interesting spin quantized hall’s cyclic transformation hologram for an urgent investigation.
This matter requires an immediate investigation Matter Very very urgent - biometric study of thumb spiraled vortex radiation emissions quantized by Hall’s spinning quantization may produce vortex index comparative holograms from the thumb Palm print denoting early analysis of Cancerous cells: The hall’s quantized Genetic hologram can be indexed by a radiation comparator on Thumb radiation. The spiral distance forming many radiative pixels as compression and expansion act along inductive capacitive compression variation is a function og genetic activity of the whole body when differentiated and diagonalised may give a clue on spin cluster cavities which may give a clue. This phenomenon has been called “current-induced spin polarization by spiral compression and expansion and the corresponding energy difference could be analysed.
Palm print indications: show palmer lesions Palm chest roentgenogram may betaken
For NIST very very very very very urgent research, copy to Imperial college of technology
Citation: Spin hall’s effect may be reevaluated for two strips top and bottom as opposite flowing current producing the opposite spin drifts Intuitively when both the spin-Hall effect and the spin-Coulomb drag are present, the spin current generated by the SHE should be reduced and therefore it is important to take a look at the combined influence of these two effects on spin transport. The directional changes of opposing magneticfield and parallel magneticfield produce an attractive and repulsive forces contributing parallel and opposing currents in Hall’s strip which can not be neglected. This produce a quantized Hall’s effective piezo electric effect of combinational circuit says Sankaravelayudhan Nandakumar by his revolutionary line of thought. Providing a Pendry cloaking strip this can be regulated forming a new design on Quantized Hall’s effect using metamaterials combination transformation optics.
A new microchip sand witch that could be designed using magnetic-light sensors along wit metamaterials a screen may revolutionalise a new type of piezo electric effect using piezo electric quartz material along wit combination of aluminium oxide etched surface forming a new piezo electric effect. A oblique folding by tangential magnetic field activity may produce electron flow tapping along the magnetic field rotational disc using magnetizing and demagnetizing cloaking screen. with MS = jMj the saturation magnetization, another material parameter, assumed constant throughout the material. Hence, if Ke > 0 (< 0) the P/H/I MA is larger (smaller) than the demagnetization energy and the magnetization will align out-of-plane (in-plane). Now, the competition between the exchange energy and the effective anisotropy determines the width of the DW. The exchange energy favors a wide DW since it prefers neighboring spins to be aligned parallel, hence, a small angle between them will cost little energy.

Palm print changes observation: General leision in the skin of palm print shifting displaced Tri-axiradius cusp with palmer keratoses.The egg shaped islanded formation or even a shadow in life line of palm print may indicate an early immune failure. The radiation produced at the Jupiter finger or Thumb may indicate reduction of white copper cells. Thumb may also be used as an indication on criminal tendencies as comparator. Radiation from the thumb may be quantized to have a selective index in such an analysis.
Thumb is producing a spiraled index and the radiation is differentiation which can be quantized analysed to evaluate any disease especially cancerous cells based on quantum hall hologram.
1)Nobel prize research works by Professors Greider and Blackburn then started to search for the specialised enzyme that makes telomere DNA - leading to the discovery of telomerase, which extends telomere DNA and delays cellular ageing.
2)My basic research on criminals with clubbed thumb with brain line upper gradient cutting through heart line towards heart line indicating an aggressive criminal tendencies. as in the case of Dr.Mayer from Chicago.
3)Refer: Cancer scanning Research works carried out by Chitra Theagarajan of Ponneri Velammal Institute of Technology ,B.Tech student Final year,Chennai.
Copy to Prof.Cam
Mr David Lefevre
Director, Educational Technology Unit
Tel: +44 (0)20 7594 9172
david.lefevre@imperial.ac.uk

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over 3 years ago

My mother was in low iron and I'm born with spina bifida occulta of category that my spine designed from two pieces joined tightly together and it's invisible until the accident happen.

In 1962 my middle bone of the spine named spinous process l-5 and s-1 split. The joints connected to spinabifida occulta.

Number of exercises prescribed to control muscles of the spine.

It was great success. I was free of pain and medication, but Iron in my blood was low and diabeth high.



I teach to injected insulin injection as well as takinf Iron liquid 10mg twice a day, hich show that my sugar level also came down.



now, please let me know how iron connected to spina bifida occulta.

my web side;www.spinabifidaocculta.com.au



All my best

helen