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The most common chemical property of benzene is that it undergoes substitution reactions. Substitution is a reaction in which an atom or group of atoms replaces a hydrogen atom in an organic molecule. The halogens, nitric acid, sulfuric acid, and alkyl halides all react with benzene to form substituted derivatives. Two, three, or more substitutions can occur on the same benzene molecule, although the ease and location on the benzene ring of these substitutions varies depending on the earlier substitutions.

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Science EncyclopediaScience & Philosophy: Ballistic galvanometer to Big–bang theoryBenzene - Structure, Properties, Benzene Derivatives, Uses, Health Issues