Many protists can cause serious illness and disease. Malaria, for example, is caused by the protist Plasmodium. Plasmodia are sporozoans and are transferred from person to person through female Anopheles mosquitoes. People who suffer from malaria experience symptoms such as shivering, sweating, high fevers, and delirium. African sleeping sickness, also known as African trypanosomiasis, is caused by another sporozoan, Trypanosoma. Trypanosoma is transmitted through the African tsetse fly. This organism causes high fever and swollen lymph nodes. Eventually the protist makes its way into the victim's brain, where it causes a feeling of uncontrollable fatigue. Giardiasis is another example of a disease caused by a protist. This illness is caused by Giardia, a sporozoan carried by muskrats and beavers. Giardiasis is characterized by fatigue, cramps, diarrhea, and weight loss. Amoebic dysentery occurs when a certain amoeba, Entamoeba histolytica, infects the large intestine of humans. It is spread through infected food and water. This organism causes bleeding, diarrhea, vomiting, and sometimes death.