The majority of the available research investigates the benefits of DHEA supplementation, but few studies discuss the possible adverse side effects associated with this hormone. One study found that prolonged DHEA treatment in rats induced liver tumors, especially in females. In male rats, sustained delivery DHEA and DHEAS treatments caused atrophy of the seminferous tubules and testes. The application of the studies on the benefits of DHEA is also limited. Much research has been conducted on rats and mice, but few clinical trials on humans have actually been performed. More research is needed on the toxicity and morphological effects of DHEA and DHEAS, as well as on its specific action on humans, before its widespread use.
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Gordon, C. "Changes in Bone Turnover Markers and Menstrual Function after Short-term DHEA in Young Women with Anorexia Nervosa." Journal of Bone and Mineral Research 14, no. 1 (1999).
Prasad, A. "Dehydroepiandrosterone DecreasesBehavioral Dispair in High- but not Low-anxiety Rats." Physiology & Behavior 62, no. 5 (1997).
Science EncyclopediaScience & Philosophy: Cyanohydrins to Departments of philosophy:Dehydroepiandrosterone (DHEA) - Dhea As A Neurosteroid, Actions Of Dhea, Marketing, Side Effects