Agent VX - Vx Poisoning, Treatment Of Vx Poisoning
nerve ethyl usually
VX nerve agent (O-ethyl S-[2-diisoproylamino-ethyl] methylphsophonothioate) is one of the most toxic substances ever developed. Like other nerve agents, it is an organophosphate. Although it is often called a nerve gas, VX is usually a clear, odorless, tasteless liquid. A tiny amount of VX, about 10 mg, absorbed through the skin, eyes, or ingested is fatal, and death usually occurs within an hour of exposure. VX poisons by binding to the enzyme cholinesterase and inactivates it. As a result, the chemical signals passed between nerve cells are transmitted uncontrollably. Symptoms of VX poisoning include constriction of the pupils, headache, runny nose, and nasal congestion, chest tightness, giddiness, anxiety, and nausea, eventually progressing to convulsions and respiratory failure. VX poisoning can be treated immediately with two antidotes: atropine and pralidoxome chloride. Because of its extreme toxicity, VX is considered a weapon of mass destruction.
Additional Topics
Chemical signals are transmitted between nerve cells by means of small molecules called neurotransmitters. One of the most common neurotransmitters in the central and peripheral nervous system is acetylcholine. Under normal conditions, acetylcholine is released from the terminal axon of one nerve cell, crosses the synaptic cleft between nerve cells, and binds with a receptor on the membrane of the…
Two antidotes exist for VX poisoning: atropine and pralidoxime chloride, also called 2-PAM. Atropine blocks one type of acetylcholine receptor on the post-synaptic nerve cell membrane. This prevents acetylcholine that is in the synaptic cleft from binding to the receptor. Pralidoxime chloride prevents VX from binding to cholinesterase. Together, these drugs have been combined in an antidote kit ca…
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