Cholesterol - History, Properties And Occurrence, Cholesterol In The Human Body, Cholesterol And Health
steroids compounds hormones organic
Cholesterol is a complex organic compound with the molecular formula C27H46O. It is a member of the biochemical family of compounds known as the lipids. Other lipids, such as the waxes, fats, and oils, share not a structural similarity (as is the case with most families of compounds), but a physical property-they are all insoluble in water, but are soluble in organic liquids.
Cholesterol belongs more specifically to a class of compounds known as the steroids. Most steroids are naturally occurring compounds that play critical roles in plant and animal physiology and biochemistry. Other steroids include sex hormones, certain vitamins, and adrenocorticoid hormones. All steroids share a common structural unit, a four-ring structure known as the perhydrocyclopentanophenanthrene ring system or, more simply, the steroid nucleus.
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Although cholesterol had been isolated as early as 1770, productive research on its structure did not begin until the twentieth century. Then, in about 1903, a young German chemist by the name of Adolf Windaus decided to concentrate on finding the molecular composition of the compound. Windaus, sometimes referred to as the Father of Steroid Chemistry, eventually worked out a detailed structure for…
Cholesterol crystallizes from an alcoholic solution as pearly white or pale yellow granules or plates. It is waxy in appearance and has a melting point of 299.3°F (148.5°C) and a boiling point of 680°F (360°C) (with some decomposition). It has a specific gravity of 1.067. Cholesterol is insoluble in water, but slightly soluble in alcohol and somewhat more soluble in eth…
Cholesterol is a critically important compound in the human body. It is synthesized in the liver and then used in the manufacture of bile, hormones, and nerve tissue. But cholesterol is also a part of the human diet. A single egg yolk for example, contains about 250 mg of cholesterol. Organ meats are particularly rich in the compound. A 3 oz (85 g) serving of beef liver, for example, contains abou…
Some of the earliest clues about possible ill effects of cholesterol on human health came from the research of Russian biologist Nikolai Anitschow in the 1910s. Anitschow fed rabbits a diet high in cholesterol and found that the animals became particularly susceptible to circulatory disorders. Post-mortem studies of the animals found the presence of plaques (clumps) of cholesterol on their arteria…
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